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PAEDIATRIC UROLOGY

8.3.2 Metaphylaxis of paediatric nephrolithiasis

Metaphylaxis of paediatric nephrolithiasis follows the principles detailed in the AWMF guidelines. (2) Dosage of metaphylactic drugs, however, requires appropriate adaptation. Examples of adapted dosages are given below.

Table 13: Metaphylaxis in paediatric nephrolithiasis: corrected dosages

Urinary excretion

30-40 ml_/kg*d-1

Sodium/potassium citrate

0.9-2.0 mEq/kg*d"1

Allopurinol

4 mg/kg*d1

Magnesium

5.7 mg/kg*d1

Ammonium chloride test

100 mg/kg*d"1

Metaphylaxis of paediatric nephrolithiasis also includes a high fluid intake, nutritional and dietetic aspects. In patients with metabolic disease (e.g. cystinuria, renal tubular acidosis, hypercalciuria, rare cases of enzymatic defects [uric acid]), only a medical metaphylaxis should be considered.